Captain Peter O'Mahony has been named on the bench for the second and final test of Ireland's tour of South Africa in Durban this weekend.
Caelan Doris will skipper the team with James Ryan set to start.
Tadhg Beirne drops into the back row at blindside flanker.
Bundee Aki misses out with what's understood to be an arm injury.
Robbie Henshaw moves from outside centre to inside centre, with Garry Ringrose coming into the side.
Conor Murray comes into the team in place of the injured Craig Casey.
And Ronan Kelleher replaces the injured Dan Sheehan.
South Africa won the first test 27-20 on Saturday.
Mayo man to captain Ireland against South Africa this weekend
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