World Player of the Year Josh van der Flier will win his 50th cap on Saturday. He lines out in an unchanged back row as Caelan Doris is named to start alongside him and Peter O’Mahony.
In the front row, Dan Sheehan has been passed fit and will start with Andrew Porter and Tadhg Furlong on either side of the scrum. Rob Herring comes in on the bench in place of Ronan Kelleher.
Ryan Baird, who came on for the injured Iain Henderson in Scotland, will partner James Ryan in the second row with Kieran Treadwell named in the replacements.
Captain Johnny Sexton will be partnered at half-back by Jamison Gibson Park and Robbie Henshaw comes into the centre to play alongside Bundee Aki. The back three of Hugo Keenan, Mack Hansen and James Lowe start for a fifth consecutive Six Nations fixture.
Sexton equalled Ronan O’Gara’s Six Nations Championship all-time points scorer record (557 points) against Scotland and can become the outright top points scorer against England this weekend.
Jimmy O’Brien come into the match day 23 to join Cian Healy, Tom O’Toole, Jack Conan, Conor Murray and Ross Byrne who all featured last weekend in Murrayfield.