Connacht's Mack Hansen is set to make his Ireland debut against Wales on Saturday.
He's been named to start on the wing for the Six Nations opener at the Aviva Stadium.
Bundee Aki partners Garry Ringrose in the midfield, with no place for Robbie Henshaw in the matchday 23.
Meanwhile, Wales head coach Wayne Pivac has handed Josh Adams a first international start at centre in the visitors team.
Dan Biggar will captain the side for the first time.
Ireland team v Wales:
- Hugo Keenan (Leinster/UCD) 16 caps 14. Andrew Conway (Munster/Garryowen) 27 caps 13. Garry Ringrose (Leinster/UCD) 37 caps 12. Bundee Aki (Connacht/Galwegians) 33 caps 11. Mack Hansen (Connacht) uncapped 10. Johnny Sexton (Leinster/St Mary's College) 101 caps CAPTAIN 9. Jamison Gibson Park (Leinster) 12 caps 1. Andrew Porter (Leinster/UCD) 40 caps 2. Ronan Kelleher (Leinster/Lansdowne) 16 caps 3. Tadhg Furlong (Leinster/Clontarf) 52 caps 4. Tadhg Beirne (Munster/Lansdowne) 25 caps 5. James Ryan (Leinster/UCD) 40 caps 6. Caelan Doris (Leinster/St Mary's College) 12 caps 7. Josh van der Flier (Leinster/UCD) 35 caps 8. Jack Conan (Leinster/Old Belvedere) 22 caps
Replacements 16. Dan Sheehan (Leinster/Lansdowne) 2 caps 17. Cian Healy (Leinster/Clontarf) 112 caps 18. Finlay Bealham (Connacht/Buccaneers) 18 caps 19. Ryan Baird (Leinster/Dublin University) 6 caps 20. Peter O'Mahony (Munster/Cork Constitution) 79 caps 21. Conor Murray (Munster/Garryowen) 92 caps 22. Joey Carbery (Munster/Clontarf) 27 caps 23. James Hume (Ulster/Banbridge) 1 cap