Donegal proved too strong for Mayo in Division 2B of the Allianz National Hurling League.
The men from the hills went for the jugular against Derek Walsh's men in Letterkenny.
The damage was done by the halftime break as Mickey McCann's side lead by 3-7 to 0-8.
The 2020 Nicky Rackard Cup winners pushed on in the second half to win by 4-18 to 0-13.