Brighton forward and Galway native Aaron Connolly has pulled out of the Republic of Ireland squad with an injury sustained in training yesterday.
Preston striker Seani Maguire has been called up as a replacement for Thursday's friendly against England and the Nations League matches against Wales and Bulgaria.
West Brom striker Callum Robinson has now been confirmed as the COVID-19 positive case in the Ireland camp and will also miss the three matches.
Swansea City's Ryan Manning has been called up and will join the squad ahead of the Wales match on Sunday.