143,000 Covid-19 vaccinations have been administered in the Republic.
That number was reached last night, and is slightly ahead of the target of 140,000.
The head of the HSE Paul Reid says there are going to be 'significant bumps' in the rollout of the Covid vaccine.
There are concerns about the delivery of the AstraZeneca jab to Ireland, which could be significantly below the levels planned.
Mr Reid said this evening that challenges with the vaccine are going to continue.