The number of people with Covid-19 being treated in intensive care units has reached 200.
The Chief Medical Officer Dr Tony Holohan is warning the situation in the country's hospitals is "stark".
The total number of Covid-positive patients in hospitals across the country has risen to 2,023 with 115 admissions in the last 24 hours.
There are currently 98 patients with Covid being treated at Mayo University Hospital - up from 80 on Saturday.
The HSE West is warning that there continues to be a very high level of infection across Mayo, Galway and Roscommon.
The 14-day incidence rate of the virus in Mayo is currently 1,635 per 100,000 people, with 2134 new cases recorded across Co Mayo over the past 2 weeks.
Dr Breda Smyth, Director of Public Health with the HSE West says that, over the next 2 weeks, our hospitals and medical services will be under significant pressure.
She says we can assist frontline workers by halting the spread of the virus in our communities.
This means Staying at Home and Staying Safe.
Dr Smyth is appealing to people to work from home if at all possible, and only to leave their homes for essential items and medicine.
Anyone who has travelled here recently from Brazil or South Africa is asked to self-isolate for 14 days after their arrival into Ireland, contact a doctor and get a Covid test - whether or not they have symptoms.