The N17 road between Claremorris and Ballindine is closed to traffic following a two vehicle collision.
Emergency services are at the scene of the two vehicle crash at the old Claremorris/Meelickmore junction.
Midwest News understands that one person has been airlifted to hospital.
Mayo County Council is advising HGV’s travelling between Galway and Sligo to divert in Tuam for Ballinrobe, while trucks coming from Sligo will be diverted at the roundabout in Claremorris.
All other motorists should follow the local diversions through Irishtown from the Ballindine-side and Ballinrobe for traffic north of Claremorris.